Synthesis of 3-(4-Pyridinyl)-, 3-(2-Chloro-4-pyridinyl)-and 3-(2-Amino-4-pyridinyl) propoxymethanephosphonic Acid

M Krečmerová, A Holý…

文献索引：Krecmerova, Marcela; Holy, Antonin; Masojidkova, Milena Collection of Czechoslovak Chemical Communications, 1995 , vol. 60, # 4 p. 670 - 680

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被引用次数: 2

摘要

Abstract Reaction of sodium salt of 4-(3-hydroxypropyl) pyridine (I) with diisopropyl p- toluenesulfonyloxymethanephosphonate (II) afforded diisopropyl ester of the corresponding phosphonomethyl derivative (III), together with 4-cyclopropylpyridine (IV). The ester III was converted into free 3-(4-pyridinyl) propoxymethanephosphonic acid (V). The synthesis of 3- (2-amino-4-pyridinyl) propoxymethanephosphonic acid (XVI) started from 4-(3- ...