Synthesis and antileishmanial activity of novel 5-(5-nitrofuran-2-y1)-1, 3, 4-thiadiazoles with piperazinyl-linked benzamidine substituents

…, JS Mojarrad, S Razmi, SK Ardestani, S Emami…

文献索引：Tahghighi, Azar; Marznaki, Farzane Rezazade; Kobarfard, Farzad; Dastmalchi, Siavoush; Mojarrad, Javid Shahbazi; Razmi, Sepideh; Ardestani, Sussan Kabudanian; Emami, Saeed; Shafiee, Abbas; Foroumadi, Alireza European Journal of Medicinal Chemistry, 2011 , vol. 46, # 6 p. 2602 - 2608

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被引用次数: 33

摘要

Abstract In order to optimize the antileishmanial activity of piperazinyl-linked 5-(5-nitrofuran- 2-yl)-1, 3, 4-thiadiazoles, we synthesized a series of 5-(5-nitrofuran-2-y1)-1, 3, 4-thiadiazoles with piperazinyl-linked benzamidine substituent as scaffold found in pentamidine related antiprotozoals. The structure of target compounds was confirmed by IR, 1 H NMR, 13 C NMR and Mass spectral data. All compounds were tested for in vitro activity against the ...