Synthesis of 2-hydroxy-3-diethylaminopropyl esters of substituted acetic acids and their pharmaceutical activity

OL Mndzhoyan, AA Gamburyan, AU Isakhanyan…

文献索引：Mndzhoyan, O. L.; Gamburyan, A. A.; Isakhanyan, A. U.; Vasilyan, S. S.; Pogosyan, A. V.; et al. Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 5 p. 338 - 341 Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 5 p. 550 - 553

全文：HTML全文

被引用次数: 1

摘要

According to this scheme, the hydrochlorides VIa-i were synthesized by amination of a mixture of III-V with excess diethylamine, followed by treatment with HCI. The mixture of III-V was obtained by the reaction of the substituted acetic acids (I)[3] with epichlorohydrin (II) in the presence of benzyltrimethylammonium chloride [4]. The formation of III-V was confirmed by TLC in the system ether-petroleum ether (12: 8), visualized with iodine vapor.