Design and synthesis of benzenesulfonamide derivatives as potent anti-influenza hemagglutinin inhibitors

G Tang, X Lin, Z Qiu, W Li, L Zhu, L Wang…

文献索引：Tang, Guozhi; Lin, Xianfeng; Qiu, Zongxing; Li, Wentao; Zhu, Lei; Wang, Lisha; Li, Shaohua; Li, Haodong; Lin, Wenbin; Yang, Mei; Guo, Tao; Chen, Li; Lee, Daniel; Wu, Jim Z.; Yang, Wengang ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 8 p. 603 - 607

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被引用次数: 12

摘要

Structural optimization of salicylamide-based hemagglutinin (HA) inhibitor 1 resulted in the identification of cis-3-(5-hydroxy-1, 3, 3-trimethylcyclohexylmethylamino) benzenesulfonamide 28 and its derivatives as potent anti-influenza agents. The lead compound 28 and its 2-chloro analogue 40 can effectively prevent cytopathic effects (CPE) caused by infection of influenza A/Weiss/43 strain (H1N1) with EC50 values of 210 and 86 ...