Letters in Organic Chemistry

Novel and Simple Methodology for the Synthesis of 3-Acetylindoles and their N-Alkyl Derivatives Using TBAB as Phase Transfer Catalyst

M Venkatanarayana, PK Dubey

文献索引：Venkatanarayana; Dubey, Pramod K. Letters in Organic Chemistry, 2011 , vol. 8, # 9 p. 656 - 662

被引用次数: 1

摘要

Using 5% aq. NaOH, a simple method for the transformation of 3-cyanoacetylindoles 2 (ae) into 3-acetylindoles 3 (ae), in good yields, is reported. Tetrabutylammoniumbromide (TBAB) is found to be an efficient phase transfer catalyst for the synthesis of N-alkyl derivatives 5 (at)

~95%

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~83%

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~96%

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~92%

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~81%

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~92%

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~94%

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~89%

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~80%

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Regioselective nitration of 3-acetylindole and its N-acyl an...

[Ottoni, Olivia; Cruz, Rosimeire; Krammer, Norbert H. Tetrahedron Letters, 1999 , vol. 40, # 6 p. 1117 - 1120]