Journal of the American Chemical Society

Diastereoselective cycloisomerizations of enediynes via palladium catalysis

BM Trost, Y Shi

文献索引：Trost; Shi Journal of the American Chemical Society, 1993 , vol. 115, # 26 p. 12491 - 12509

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被引用次数: 88

摘要

Abstract: Considerations of atom economy drive a search for reactions that are simple additions which, performed intramolecularly, are cycloisomerizations. Exposure of acyclic enediynes to a catalyst generated by mixing a Pd (0) complex with acetic acid normally in the presence of a phosphine ligand creates [5.6. 5] and [6.6. 5] tricycles with extraordinary diastereoselectivity of remote stereogenic centers. Effects of substituents on the tethers as ...