Combined CH functionalization/CN bond formation route to carbazoles

WCP Tsang, N Zheng, SL Buchwald

文献索引：Barder, Timothy E.; Walker, Shawn D.; Martinelli, Joseph R.; Buchwald, Stephen L. Journal of the American Chemical Society, 2005 , vol. 127, # 13 p. 4685 - 4696

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被引用次数: 472

摘要

A new method in which a series of substituted carbazoles is efficiently produced by the combination of an amide and an arene is described. The key feature of this method is the palladium-catalyzed tandem directed CH functionalization and amide arylation. The method tolerates substitution on either ring of the biaryl amide substrates, and the products can be assembled in a simple two-step protocol from readily available reagents. The Pd (0) ...