Direct synthesis of polysubstituted quinoline derivatives by InBr3-promoted dimerization of 2-ethynylaniline derivatives

N Sakai, K Annaka, T Konakahara

文献索引：Sakai, Norio; Annaka, Kimiyoshi; Konakahara, Takeo Journal of Organic Chemistry, 2006 , vol. 71, # 9 p. 3653 - 3655

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被引用次数: 53

摘要

Cyclization reactions of several ethynylanilines were similarly run under the above optimal conditions, and the results are shown in Table 2. For example, the use of a substrate containing an electron-rich group afforded the desired product 3b in 79% yield (entry 2). The use of 2c gave the 2,4,6,7-tetrasubstituted quinoline 3c in good yield (entry 3). With the exception of the 4-fluoro-substituted aniline 2d, the use of an ethynylaniline derivative containing an ...