Conjugation of a novel histidine derivative to biomolecules and labelling with [99m Tc (OH 2) 3 (CO) 3]+

…, B Spingler, N Metzler-Nolte, R Alberto

文献索引：Van Staveren, Dave R.; Mundwiler, Stefan; Hoffmanns, Ulrich; Pak, Jae Kyoung; Spingler, Bernhard; Metzler-Nolte, Nils; Alberto, Roger Organic and Biomolecular Chemistry, 2004 , vol. 2, # 18 p. 2593 - 2603

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被引用次数: 62

摘要

The new histidine derivative 3-{1-[3-(9H-fluoren-9-ylmethoxycarbonylamino)-propyl]-1H- imidazol-4-yl}-2-(3-trimethylsilanyl-ethylcarboxyamino)-propionic acid methyl ester (7) has been prepared via alkylation of the histidine urea derivative (7S)-5, 6, 7, 8-tetrahydro-7- (methoxycarbonyl)-5-oxoimidazo-[1, 5-c]-pyrimidine (2) with Fmoc-protected 3-iodopropyl- amine, followed by ring opening with 2-trimethylsilylethanol. After Fmoc cleavage by ...