Synthesis and antimicrobial evaluation of guanylsulfonamides

PR Patel, C Ramalingan, YT Park

文献索引：Patel, Pratik R.; Ramalingan, Chennan; Park, Yong-Tae Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 23 p. 6610 - 6614

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被引用次数: 21

摘要

A series of guanylsulfonamides, 2-amino-9-[2-substituted-4-(4-substituted piperidin-1- sulfonyl) phenyl]-1, 9-dihydropurin-6-ones, was synthesized by adopting reductive aminoformylation of 2-amino-5-nitro-6-[4-(piperidin-1-sulfonyl) phenylamino]-3H-pyrimidin-4- one and subsequent intramolecular ring condensation as key steps. All the guanylsulfonamides were assayed for their in vitro antibacterial activities against ...