Novel analgesic-antiinflammatory salicylates

J Hannah, WV Ruyle, H Jones, AR Matzuk…

文献索引：Hannah,J. et al. Journal of Medicinal Chemistry, 1978 , vol. 21, p. 1093 - 1100

全文：HTML全文

被引用次数: 74

摘要

5-(2, 4-Difluorophenyl) salicylic acid, diflunisal (25), is the best compound, in terms of both efficacy and safety, from over 500 salicylates investigated in our laboratories. It is a chemically distinct, nonacetylating salicylic acid, more active than aspirin as an analgesic and antiinflammatory agent and superior in duration of action and therapeutic index. Some recent clinical and biochemical observations are briefly discussed.