The Journal of Organic Chemistry

Zinc dication inclusion complexes of endodentate tripodands as carbonic anhydrase-inspired artificial esterases

R Jairam, PG Potvin

文献索引：Jairam, Rick; Potvin, Pierre G. Journal of Organic Chemistry, 1992 , vol. 57, # 15 p. 4136 - 4141

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被引用次数: 18

摘要

Facile syntheses are reported for three endo-tridentate tris-imidazole podands 1-3, two of which also bear basic amino residues, designed to reproduce the active site of carbonic anhydrase. The architecture was tested for the ability to bind Zn2+ in a" biomimetic" fashion and for the esterase activity of the Zn2+ complexes. Complexation of Zn2+ and Co" was studied by pH-titrimetry and NMR and W-vis spectrometry and was found to be moderate. ...