Tetrahedron Letters

Co-catalyzed mild and chemoselective reduction of phenyl esters with NaBH 4: a practical synthesis of (R)-tolterodine

AR Jagdale, A Sudalai

文献索引：Jagdale, Arun R.; Sudalai, Arumugam Tetrahedron Letters, 2008 , vol. 49, # 23 p. 3790 - 3793

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被引用次数: 18

摘要

CoCl2 catalyzes effectively the chemoselective reduction of phenyl carboxylic esters to the corresponding saturated alcohols in high yields using NaBH4 at ambient conditions. By employing this methodology, the synthesis of (R)-tolterodine, a muscarinic receptor antagonist, has been achieved in high yield and optical purity.