S-Methyl N, N-diethylthiocarbamate sulfone, a potential metabolite of disulfiram and potent inhibitor of low K m mitochondrial aldehyde dehydrogenase

…, AN Nelson, AH Fauq, ZH Shriver, KA Veverka…

文献索引：Mays, Dennis C.; Nelson, Albert N.; Fauq, Abdul H.; Shriver, Zachary H.; Veverka, Karen A.; et al. Biochemical Pharmacology, 1995 , vol. 49, # 5 p. 693 - 700

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被引用次数: 23

摘要

Disulfiram inhibits hepatic aldehyde dehydrogenase (ALDH) causing an accumulation of acetaldehyde after ethanol ingestion. It is thought that disulfiram is too short-lived in vivo to directly inhibit ALDH, but instead is biotransformed to reactive metabolites that inhibit the enzyme. S-Methyl N, N-diethylthiocarbamate (MeDTC) sulfoxide has been identified in the blood of animals given disulfiram and is a potent inhibitor of ALDH (Hart and Faiman, ...