Activation of peroxisome proliferator-activated receptor γ (PPARγ) by nitroalkene fatty acids: importance of nitration position and degree of unsaturation
…, PK Smitherman, TE Akiyama, HB Wood…
文献索引：Gorczynski, Michael J.; Smitherman, Pamela K.; Akiyama, Taro E.; Wood, Harold B.; Berger, Joel P.; King, S. Bruce; Morrow, Charles S. Journal of Medicinal Chemistry, 2009 , vol. 52, # 15 p. 4631 - 4639
Nitroalkene fatty acids are potent endogenous ligand activators of PPARγ-dependent transcription. Previous studies with the naturally occurring regioisomers of nitrolinoleic acid revealed that the isomers are not equivalent with respect to PPARγ activation. To gain further insight into the structure− activity relationships between nitroalkenes and PPARγ, we examined additional naturally occurring nitroalkenes derived from oleic acid, 9-nitrooleic ...
