Expedient Synthesis, on Large Scale, of Aliphatic Chaetomellic Anhydrides from N-Allyl-2, 2-dichlorocarboxyamides

…, F Roncaglia, V Giangiordano, AF Parsons

文献索引：Ghelfi, Franco; Pattarozzi, Mariella; Roncaglia, Fabrizio; Giangiordano, Valerio; Parsons, Andrew F. Synthetic Communications, 2010 , vol. 40, # 7 p. 1040 - 1051

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被引用次数: 12

摘要

Chaetomellic anhydride A and an analog (with two additional carbons) were obtained, on a preparative scale, starting from amides derived from the acylation of 2-(2-propenylamino) pyridine with 2, 2-dichloropalmitic or 2, 2-dichlorostearic acid. An alternative approach, in which the methyl substituent of the target anhydride is introduced by the carboxylic acid reactant and the long aliphatic chain is added through the allylamino moiety, proved ...