Novel substituted (pyridin-3-yl) phenyloxazolidinones: antibacterial agents with reduced activity against monoamine oxidase A and increased solubility

…, D Carcanague, G Ioannidis, R Illingworth…

文献索引：Reck, Folkert; Zhou, Fei; Eyermann, Charles J.; Kern, Gunther; Carcanague, Dan; Ioannidis, Georgine; Illingworth, Ruth; Poon, Grace; Gravestock, Michael B. Journal of Medicinal Chemistry, 2007 , vol. 50, # 20 p. 4868 - 4881

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被引用次数: 38

摘要

Oxazolidinones represent a new and promising class of antibacterial agents. Current research in this area is mainly concentrated on improving the safety profile and the antibacterial spectrum. Oxazolidinones bearing a (pyridin-3-yl) phenyl moiety (eg, 3) generally show improved antibacterial activity compared to linezolid but suffer from potent monoamine oxidase A (MAO-A) inhibition and low solubility. We now disclose the finding ...