Diaryl dihydropyrazole-3-carboxamides with significant in vivo antiobesity activity related to CB1 receptor antagonism: Synthesis, biological evaluation, and molecular …

BK Srivastava, A Joharapurkar, S Raval…

文献索引：Srivastava, Brijesh Kumar; Joharapurkar, Amit; Raval, Saurin; Patel, Jayendra Z.; Soni, Rina; Raval, Preeti; Gite, Archana; Goswami, Amitgiri; Sadhwani, Nisha; Gandhi, Neha; Patel, Harilal; Mishra, Bhupendra; Solanki, Manish; Pandey, Bipin; Jain, Mukul R.; Patel, Pankaj R. Journal of Medicinal Chemistry, 2007 , vol. 50, # 24 p. 5951 - 5966

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被引用次数: 53

摘要

A number of analogues of diaryl dihydropyrazole-3-carboxamides have been synthesized. Their activities were evaluated for appetite suppression and body weight reduction in animal models. Depending on the chemical modification of the selected dihydropyrazole scaffold, the lead compounds the bisulfate salt of (±)-5-(4-chlorophenyl)-1-(2, 4-dichlorophenyl)-4, 5- dihydro-1 H-pyrazole-3-carboxylic acid morpholin-4-ylamide 26 and the bisulfate salt of (-) ...