Synthesis of phenalene and acenaphthene derivatives as new conformationally restricted ligands for melatonin receptors

…, M Mathé-Allainmat, J Andrieux…

文献索引：Kloubert, Stephane; Mathe-Allainmat, Monique; Andrieux, Jean; Langlois, Michel Synthetic Communications, 2000 , vol. 30, # 16 p. 2873 - 2887

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被引用次数: 36

摘要

Conformationally restricted phenalene and acenaphthene derivatives 5 were synthesized from phenalen-1-one and acenaphthen-1-one derivatives using the Horner-Emmons reaction. The amines were prepared through the corresponding isocyanates by the Curtius reaction on the acids or by the reduction of the nitriles. Amido derivatives (R3= Me, Et, n-Pr, c- Pr) were prepared by acylation of the amines with the appropriate anhydrides or acid ...