6-Substituted and 5, 6-disubstituted derivatives of uridine: stereoselective synthesis, interaction with uridine phosphorylase, and in vitro antitumor activity

…, AK Drabikowska, JA Vilpo, T Kulikowski…

文献索引：Felczak, Krzysztof; Drabikowska, Alicja K.; Vilpo, Juhani A.; Kulikowski, Tadeusz; Shugar, David Journal of Medicinal Chemistry, 1996 , vol. 39, # 8 p. 1720 - 1728

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被引用次数: 24

摘要

Stereoselective procedures are described for the synthesis of 6-alkyluridines by Lewis acid- catalyzed condensation of (a) trimethylsilylated 6-alkyl-4-alkylthiouracils with 1-O-acetyl-2, 3, 5-tri-O-benzoyl-β-d-ribofuranose (ABR) and (b) trimethylsilylated 6-alkyl-3-benzyluracils with ABR. The 4-methylthio group was subsequently removed with the use of 1 N trifluoroacetic acid and the 3-benzyl group by a new modified procedure with the use of the complex ...