Tetrahedron

1, 2, 3-Triazolo [5, 1-b] thiazoles. Part 2 Lithiation experiments leading to 2, 4-disubstituted thiazoles

G Jones, H Ollivierre, LS Fuller, JH Young

文献索引：Jones, Gurnos; Ollivierre, Hermione; Fuller; Young Tetrahedron, 1991 , vol. 47, # 16-17 p. 2861 - 2870

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被引用次数: 4

摘要

3-Methyltriazolothiazole (2) and 3-phenyltriazolothiazole (3) were regiospecifically lithiated at position 6, triazolothiazole (1) at position 6 and 3 with the former predominating. The lithiated triazolothiazoles (4),(10) and (11) reacted with a number of electrophiles to give x: 6- disubstituted triazolothiazoles, which could be converted into 2, 4-disubstituted thiazoles.