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Discovery of triazine mimetics as potent antileishmanial agents

K Chauhan, M Sharma, R Shivahare…

文献索引:Chauhan, Kuldeep; Sharma, Moni; Shivahare, Rahul; Debnath, Utsab; Gupta, Suman; Prabhakar, Yenamandra S.; Chauhan, Prem M. S. ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 11 p. 1108 - 1113

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被引用次数: 10

摘要

The World Health Organization has classified the leishmaniasis as a major tropical disease. The discovery of new compounds for leishmaniasis is therefore a pressing concern for the anti-infective research program. We have synthesized 19 compounds of triazine dimers as novel antileishmanial agents. Most of the synthesized derivatives exhibited better activity against intracellular amastigotes (IC50 ranging from 0.77 to 10.32 μM) than the control, ...