AlCl3-mediated Defluorinative Diarylhydroxylation Transformation of CF3: Chemoselective Arylation of CF3 and Chlorocarbonyl Groups Attached to Aromatic Rings
The CF 3 group in 4-trifluoromethylbenzoyl chloride is efficiently diarylated and converted into a diarylhydroxymethyl group by treatment with AlCl 3 in the presence of an excess amount of halobenzene (C 6 H 5 X; X= F, Cl, and Br). The diarylation is followed by arylation of the chlorocarbonyl group to afford triarylated products, diarylhydroxymethylated benzophenones. The employment of TfOH in place of AlCl 3 promotes the exclusive ...
