Studies of the Selective O-Alkylation and Dealkylation of Flavonoids. XI. A New Convenient Method for Synthesizing 3, 5, 7-Trihydroxy-8-methoxyflavones from 7- …

T Horie, M Tsukayama, Y Kawamura, M Seno…

文献索引：Horie; Tsukayama; Kawamura; Seno; Yamamoto Bulletin of the Chemical Society of Japan, 1988 , vol. 61, # 2 p. 441-447

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被引用次数: 9

摘要

The 3-or 5-methoxyl group in the ditosylates of 5, 7-dihydroxy-3, 4′, 8-trimethoxy-and 3, 7- dihydroxy-4′, 5, 8-trimethoxyflavones was quantitatively demethylated with anhydrous aluminum bromide in acetonitrile to give the corresponding monohydroxyflavones, which were easily hydrolyzed into 3, 5, 7-trihydroxy-4′, 8-dimethoxyflavone. On the basis of the results, the following convenient method for synthesizing 3, 5, 7-trihydroxy-8- ...