Total Synthesis of Everninomicin 13,384??1—Part 1: Retrosynthetic Analysis and Synthesis of the A1B (A) C Fragment

…, H Suzuki, KC Fylaktakidou, O Baudoin…

文献索引：Nicolaou; Rodriguez, Rosa Maria; Mitchell, Helen J.; Suzuki, Hideo; Fylaktakidou, Konstantina C.; Baudoin, Olivier; Van Delft, Floris L. Chemistry - A European Journal, 2000 , vol. 6, # 17 p. 3095 - 3115

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被引用次数: 68

摘要

Abstract In this first of a series of four articles we introduce everninomicin 13,384-1 (1), a powerful antibiotic effective against drug resistant bacteria, as a target for total synthesis and discuss its retrosynthetic analysis. From the three defined fragments required for the synthesis (2: A 1 B (A) C fragment; 4: DE fragment; 5: FGHA 2 fragment), we describe herein two approaches to the A 1 B (A) C block. The first strategy relied on an olefin metathesis ...