Potential Purine Antagonists. XI. Synthesis of some 9-aryl (alkyl)-2, 6-disubstituted purines

HC Koppel, RK Robins

文献索引：Koppel; Robins Journal of the American Chemical Society, 1958 , vol. 80, p. 2751,2753

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被引用次数: 33

摘要

11, R= CIC, jH4) was prepared from uramil in an over-all yield of 12%. This work was extended to include the preparation of-9-ethyl,-9-isobutyl and-9-methyl-2, B-dihydroxypurine by the removal of the 8-mercapto group with Raney nickel. Since a rather large quantity of uramil was required for this study, it was found convenient to nitrosate barbituric acid after the manner of Bayer6 and to reduce this product (violuric acid) with sodium hydrosulfite to ...