Biochemistry

Biochemical and thermodynamic characterization of compounds that bind to RNA hairpin loops: toward an understanding of selectivity

JR Thomas, X Liu, PJ Hergenrother

文献索引：Thomas, Jason R.; Liu, Xianjun; Hergenrother, Paul J. Journal of the American Chemical Society, 2005 , vol. 127, # 36 p. 12434 - 12435

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被引用次数: 40

摘要

Elucidation of the molecular forces governing small molecule-RNA binding is paramount to the progress of rational design strategies. The extensive characterization of the aminoglycoside-16S rRNA A-site interaction has deepened our understanding of how aminoglycosides bind to their target and exert their antimicrobial effects. However, to date no other RNA binding compounds have undergone such rigorous evaluation, and in general ...