During the course of our work on the synthesis of new thiophene derivatives with therapeutic interest,',* we needed reasonable quantities of new P-aminoacids which are versatile building-blocks in heterocyclic chemistry and in the synthesis of peptid0mimetics.'-'We previously reported the preparation and the chemical reactivity of several P-amino-P- arylpropionic acid derivatives (Scheme I)."'" The present work describes the multigram ...