N-(4-Isoxazolylthiazol-2-yl) oxamic acid derivatives as potent orally active antianaphylactic agents

D Chiarino, G Grancini, V Frigeni, I Biasini…

文献索引：Chiarino; Grancini; Frigeni; Biasini; Carenzi Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 600 - 605

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被引用次数: 18

摘要

A series of N-(4-isoxazolylthiazol-2-yl) oxamic acid derivatives was synthesized and tested on the passive cutaneous anaphylaxis (PCA) model in rats to verify its potential antianaphylactic activity. These compounds were prepared by reaction of an appropriate bromoacetylisoxazole with thiourea to give the corresponding aminothiazole and subsequent condensation with an oxalic acid monoester chloride to yield, following the ...