Abstract The synthesis and structural elucidation of some novel 5, 5′-disubstituted spiro and nonspiro-bis-hydantoins are reported. The Bucherer Burge's method has been modified for the preparation of some 5, 5′-substituted bis (imidazolidine-2, 4-dione) derivatives starting with diketones (1–5) and dialdehydes (6, 7). In some cases, diastereoisomeric mixtures of compounds were obtained. The resulting bis-hydantoins (8–11, 13, 14) have ...