Inhibitory activity of Brazilian green propolis components and their derivatives on the release of cys-leukotrienes

…, K Hasumi, T Tatefuji, K Hashimoto, H Koshino…

文献索引：Tani, Hiroko; Hasumi, Keiko; Tatefuji, Tomoki; Hashimoto, Ken; Koshino, Hiroyuki; Takahashi, Shunya Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 1 p. 151 - 157

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被引用次数: 30

摘要

The effects of Brazilian green propolis ethanol extract on Cry j1-induced cys-leukotrienes and histamine release from peripheral leukocytes of patients with allergic rhinitis were investigated. One of the key mechanisms for the anti-allergic properties of the extract was revealed to be the suppression of cys-LTs release. Furthermore, a series of propolis components and their phenethyl esters were synthesized and evaluated as inhibitors of ...