Discovery of CYT997: a structurally novel orally active microtubule targeting agent

…, MF Harte, X Bu, E Fantino, M Joffe, H Sikanyika…

文献索引：Burns, Christopher J.; Harte, Michael F.; Bu, Xianyong; Fantino, Emmanuelle; Joffe, Max; Sikanyika, Harrison; Su, Stephen; Tranberg, C. Elisabet; Wilson, Neil; Charman, Susan A.; Shackleford, David M.; Wilks, Andrew F. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 16 p. 4639 - 4642

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被引用次数: 19

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... CYT997 was discovered as a potent tubulin polymerization inhibitor possessing potent cytotoxic activity against a range of cancer cells. Details of SAR studies, pharmacokinetic investigations and synthesis of compounds leading to the discovery of CYT997 are reported.