Antimycobacterial activity evaluation, time-kill kinetic and 3D-QSAR study of C-(3-aminomethyl-cyclohexyl)-methylamine derivatives

D Kumar, KK Raj, MA Bailey, T Alling, T Parish…

文献索引：Kumar, Deepak; Raj, K. Kranthi; Bailey, Maiann; Alling, Torey; Parish, Tanya; Rawat, Diwan S. Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 5 p. 1365 - 1369

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被引用次数: 17

摘要

A series of C-(3-aminomethyl-cyclohexyl)-methylamine derivatives were synthesized and evaluated for their antitubercular activity. Some of the compounds exhibited potent activity against Mycobacterium tuberculosis H37Rv. One of the compound having t-butyl at para position of the benzene ring showed excellent activity even better than the standard drug ethambutol with MIC value 1.1±0.2 μM. The time-kill kinetics study of two most active ...