Imine derivatives as new potent and selective CB 2 cannabinoid receptor agonists with an analgesic action

…, M Tatsuzuki, M Yoshinaga, I Iida, T Yamaguchi…

文献索引：Ohta, Hiroshi; Ishizaka, Tomoko; Tatsuzuki, Makoto; Yoshinaga, Mitsukane; Iida, Izumi; Yamaguchi, Tomomi; Tomishima, Yasumitsu; Futaki, Nobuko; Toda, Yoshihisa; Saito, Shuji Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 3 p. 1111 - 1124

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被引用次数: 41

摘要

In this study, a novel series of CB2 receptor agonist imine derivatives, 1–6, was synthesized and evaluated for activity against the CB2 receptor. In a previous paper we reported the synthesis and SARs of thiazole derivative 1, a potent CB2 receptor agonist, but we had not assessed chemical modifications of the 5-membered heteroring of 1. In the present study, we therefore tried chemically modifying the 5-membered heteroring of 1 in an attempt to ...