Abstract The chemical study of Sechium mexicanum roots led to the isolation of the two new saponins {3-O-β-D-glucopyranosyl (1 [RIGHTWARDS ARROW] 3)-β-D-glucopyranosyl-2β, 3β, 16α, 23-tetrahydroxyolean-12-en-28-oic acid 28-O-α-L-rhamnopyranosyl-(1 [RIGHTWARDS ARROW] 3)-β-D-xylopyranosyl-(1 [RIGHTWARDS ARROW] 4)-α-L- rhamnopyranosyl-(1 [RIGHTWARDS ARROW] 2)-α-L-arabinopyranoside}(1) and {3-O-β-D ...