Synthesis and antimycobacterial activity of isoniazid derivatives from renewable fatty acids

…, JB Cantos, CRM D'Oca, KL Soares, TS Coelho…

文献索引：Rodrigues, Marieli O.; Cantos, Jessica B.; D'Oca, Caroline R. Montes; Soares, Karina L.; Coelho, Tatiane S.; Piovesan, Luciana A.; Russowsky, Dennis; Da Silva, Pedro A.; D'Oca, Marcelo G. Montes Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 22 p. 6910 - 6914

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被引用次数: 18

摘要

Abstract This work describes the synthesis of a series of fatty acid hydrazide derivatives of isoniazid (INH). The compounds were tested against Mycobacterium tuberculosis H37Rv (ATCC 27294) as well as INH-resistant (ATCC 35822 and 1896 HF) and rifampicin-resistant (ATCC 35338) M. tuberculosis strains. The fatty acid derivatives of INH showed high antimycobacterial potency against the studied strains, which is desirable for a ...