Continuous flow hydrogenation of functionalized pyridines

…, E Petricci, TN Glasnov, M Taddei…

文献索引：Irfan, Muhammed; Petricci, Elena; Glasnov, Toma N.; Taddei, Maurizio; Kappe, C. Oliver European Journal of Organic Chemistry, 2009 , # 9 p. 1327 - 1334

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被引用次数: 24

摘要

Abstract The heterogeneous hydrogenation of substituted pyridines has been accomplished by employing a continuous flow hydrogenation device that incorporates in situ hydrogen generation by electrolysis of H 2 O and pre-packed catalyst cartridges. In general, the hydrogenation reactions proceeded smoothly regardless of the supported precious metal catalyst (Pd/C, Pt/C, or Rh/C). By using 30–80 bar of hydrogen pressure at 60–80 C full ...