Advances toward new antidepressants with dual serotonin transporter and 5-HT1A receptor affinity within a class of 3-aminochroman derivatives. Part 2

…, M Chlenov, M Kagan, J Golembieski…

文献索引：Hatzenbuhler, Nicole T.; Baudy, Reinhardt; Evrard, Deborah A.; Failli, Amedeo; Harrison, Boyd L.; Lenicek, Steven; Mewshaw, Richard E.; Saab, Annmarie; Shah, Uresh; Sze, Jean; Zhang, Minsheng; Zhou, Dahui; Chlenov, Michael; Kagan, Michael; Golembieski, Jeannette; Hornby, Geoffrey; Lai, Margaret; Smith, Deborah L.; Sullivan, Kelly M.; Schechter, Lee E.; Andree, Terrance H. Journal of Medicinal Chemistry, 2008 , vol. 51, # 21 p. 6980 - 7004

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被引用次数: 20

摘要

Novel compounds combining a 5-HT1A moiety (3-aminochroman scaffold) and a 5-HT transporter (indole analogues) linked through a common basic nitrogen via an alkyl chain attached at the 1-or 3-position of the indole were evaluated for dual affinity at both the 5-HT reuptake site and the 5-HT1A receptor. Compounds of most interest were found to have a 5- carbamoyl-8-fluoro-3-amino-3, 4-dihydro-2 H-1-benzopyran linked to a 3-alkylindole ( ...