Tetrahedron: Asymmetry

Enzyme assisted synthesis of enantiomerically pure δ-lactones

B Haase, MP Schneider

文献索引：Haase, Bernhard; Schneider, Manfred P. Tetrahedron: Asymmetry, 1993 , vol. 4, # 5 p. 1017 - 1026

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被引用次数: 43

摘要

Abstract Both enantiomeric series of a wide variety of optically pure 6-alkylated δ-lactones- saturated as well as unsaturated-were prepared via an enzyme mediated route. The key reaction step is the nucleophilic ring opening of enantiomerically pure alkyl-oxiranes, accessible via the corresponding β-hydroxythioethers which can be obtained enantiomerically pure via enzyme catalyzed kinetic resolutions.