Tetrahedron: Asymmetry

The resolution of tertiary α-acetylene-acetate esters by the lipase from Candida cylindracea

D O'Hagan, NA Zaidi

文献索引：O'Hagan, David; Zaidi, Naveed A. Tetrahedron: Asymmetry, 1994 , vol. 5, # 6 p. 1111 - 1118

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被引用次数: 39

摘要

Abstract The resolution of tettiary alcohols using the Candida cylindracea lipase is explored. In particular strategies are deployed to limit nonenzmatic hydrolysis of the tertiary acetate substrates in buffer, such that a full range of the steric requirements and limitations for successful resolutions can be explored.