D (−)??and L (+)?螃摸?Carboxyglutamic Acid (Gla): Resolution of Synthetic Gla Derivatives

…, M Oppliger, P Thanei, R Schwyzer

文献索引：Maerki; Oppliger; Thanei; Schwyzer Helvetica chimica acta, 1977 , vol. 60, # 3 p. 798 - 806

全文：HTML全文

被引用次数: 11

摘要

Abstract The chemical resolution of γ, γ′-di-t-butyl DL-N-benzyloxycarbonyl-γ-carboxy- glutamate is described in detail (preliminary account see [1]). The D (−)-derivative was obtained as a crystalline quinine salt, and the L (+)-derivative as a crystalline salt with (−)- ephedrine in yields of 44 and 70%, respectively. Physical data are indicated for the enantiomers of γ, γ′-di-t-butyl N-benzyloxycarbonyl-γ-carboxyglutamate, γ, γ′-di-t-butyl ...