Tetrahedron letters

Phenylacetyloxymethylene, a carboxyl protecting group removable with immobilized penicillin acylase, useful in benzyl penicillin chemistry

…, D Faiardi, C Fuganti, P Grasselli, A Lazzarini

文献索引：Baldaro; Faiardi; Fuganti; Grasselli; Lazzarini Tetrahedron Letters, 1988 , vol. 29, # 36 p. 4623 - 4624

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被引用次数: 17

摘要

Abstract The phenylacetyloxymethylene group serves to protect the carboxyl group of benzylpenicillin sulphoxide (2a) during the transformation into 7-ADCA and 7β-amino-3- methoxyceph-3-em-4-carboxylic acid (9), being removed together with the 7-phenylacetyl side chain by means of immobilized penicillin acylase in a single step.