Australian journal of chemistry

Synthesis of deuterated aminocaproyl linkers

A Anastasiadis, F Separovic, J White

文献索引：Anastasiadis, Aphrodite; Separovic, Frances; White, Jonathan Australian Journal of Chemistry, 2001 , vol. 54, # 12 p. 747 - 750

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被引用次数: 4

摘要

Abstract Gramicidin A (gA) analogues with a biotin attached to the C-terminus by an aminocaproyl linker are used as ion channels in the AMBRI® biosensor and are referred to as biotinylated gA. In order to examine the conformation and dynamics of the aminocaproyl linker by 2 H solid-state nuclear magnetic resonance, the synthesis of deuterated aminocaproic acid is required. We report on the synthesis of (D 10)-6-aminocaproic acid ...