Journal of medicinal chemistry

Synthesis and. beta.-adrenergic antagonist activity of stereoisomeric practolol and propranolol derivatives

K Leftheris, M Goodman

文献索引：Leftheris, Katerina; Goodman, Murray Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 216 - 223

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被引用次数: 18

摘要

A series of stereoisomeric practolol and propranolol derivatives has been synthesized in which the N-isopropyl group of the drug was replaced by an asymmetric heptanoic acid terminated by a substituted p-toluidide or p-(trifluoromethy1) anilide. The asymmetric epoxide, 3-(p-acetamidophenoxy)-1, 2-epoxypropane, was allowed to react with a preformed enantiomeric 6-aminoheptanoic acid amide to yield the stereoisomeric ...