Synthesis and biological activity of sulphostin analogues, novel dipeptidyl peptidase IV inhibitors

…, T Akiyama, Y Umezawa, K Yamamoto, M Nagai…

文献索引：Abe, Masatoshi; Akiyama, Tetsuo; Umezawa, Yoji; Yamamoto, Keiichiro; Nagai, Masashi; Yamazaki, Hiroko; Ichikawa, Yuh-Ichiro; Muraoka, Yasuhiko Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 3 p. 785 - 797

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被引用次数: 30

摘要

The structure of sulphostin (1), a novel dipeptidyl peptidase IV (DPP-IV) inhibitor, is consisted of three key functional groups, including a characteristic amino (sulfoamino) phosphinyl group, on a piperidine ring. To examine the relationship between its structure and the inhibitory activity against DPP-IV, various analogues were synthesized and their activities were investigated. These results indicated that all of the functional groups on the ...