Tetrahedron

Ti-TADDOLate-catalyzed, highly enantioselective addition of alkyl-and aryl-titanum derivatives to aldehydes

B Weber, D Seebach

文献索引：Weber, Beat; Seebach, Dieter Tetrahedron, 1994 , vol. 50, # 25 p. 7473 - 7484

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被引用次数: 184

摘要

Toluene-ether or toluene-hexane solutions of aryl and alkyl triisopropoxy titanium reagents (free of Li, Mg, or Zn salts) are prepared from the corresponding Li or Grignard reagents and ClTi (OiPr) 3, with careful removal of salts (centrifugation of LiCl or of dioxane· MgX2, and addition of 12-crown-4). The solutions of the organotitanium compounds are combined with one equiv. of an aldehyde and 0.2 equiv. of (R, R)-diisopropoxy-(α, α, α′, α′-tetraphenyl ...