Tetrahedron letters

Solid phase synthesis of 2-aminobutadienes using a piperazine linker

NW Hird, K Irie, K Nagai

文献索引：Hird, Nicholas W.; Irie, Kazuyuki; Nagai, Katsunori Tetrahedron Letters, 1997 , vol. 38, # 40 p. 7111 - 7114

全文：HTML全文

被引用次数: 47

摘要

A series of resin-bound 4-substituted-2-aminobutadienes have been synthesised via Wittig reaction with polymer supported 2-(N-piperazino) prop-1-enyl-1-triphenylphosphonium bromide. The use of piperazine provides a readily cleavable enamine linker for attachment of ketones that is compatible with anion chemistry.