Optimization of potency and pharmacokinetics of tricyclic indole derived inhibitors of HCV NS5B polymerase. Identification of ester prodrugs with improved oral …
S Venkatraman, F Velazquez, S Gavalas, W Wu…
文献索引：Bioorganic and Medicinal Chemistry, , vol. 22, # 1 p. 447 - 458
... Bioorganic & Medicinal Chemistry. ... Treatment of alcohol 21 with methanesulfonyl chloride and triethylamine resulted in formation of benzylic chloride 22 which was converted to the indazole analog 24 using chemistry previously described. ...
