Catalytic Asymmetric Aldol-Type Reactions Using a Chiral (Acyloxy) borane Complex.

K Ishihara, T Maruyama, M Mouri, Q Gao…

文献索引：Ishihara, Kazuaki; Maruyama, Tohru; Mouri, Makoto; Gao, Qingzhi; Furuta,Kyoji; Yamamoto, Hisashi Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 11 p. 3483 - 3491

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被引用次数: 69

摘要

In the presence of 20 mol% of a chiral (acyloxy) borane (CAB) complex prepared from BH 3· THF and a chiral mono-O-acylated tartaric acid, achiral silyl enol ethers or ketene silyl acetals react with achiral aldehydes to afford the corresponding aldol-type adducts in good yields with high enantio-and diastereoselectivities. Furthermore, the reactivity of aldol-type reactions can be improved without reducing the enantioselectivity by use of 10—20 mol% ...