Bioorganic & Medicinal Chemistry Letters

Oxadiazole mannich bases: Synthesis and antimycobacterial activity

MA Ali, M Shaharyar

文献索引：Ali, Mohamed Ashraf; Shaharyar, Mohammad Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 12 p. 3314 - 3316

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被引用次数: 133

摘要

A series of oxadiazole mannich bases were synthesized by reacting oxadiazole derivatives, dapsone and appropriate aldehyde in the presence of methanol. The synthesized compounds were evaluated for antimycobacterial activity against M. tuberculosis H37Rv and INH resistant M. tuberculosis. Among the synthesized compounds, compound (4) 3-{2-furyl [4-(4-{2-furyl [5-(2-naphthyloxymethyl)-2-thioxo-2, 3-dihydro-1, 3, 4-oxadiazol-3-yl] ...